Effectiveness of Azadirachta Indica Leaf Extract Against Transforming Growth Factor-β Levels in Swiss Mice Inoculated by Plasmodium berghei ANKA

Ainun Najib, Adieba Warda Hayya, Dea Amanda Caressa, Mulya Agustina, Nyoman Suci Widyastiti

Abstract


Malaria is one of the health problems for the world's population in tropical and subtropical regions. Malaria infection is caused by the protozoa Plasmodium spp. This study aims to determine the effectiveness of A. indica Leaf extract against TGF-β levels in Swiss mice inoculated with Plasmodium berghei ANKA (PbA). This study used true experimental with a post-test design only control group design which used Swiss mice subjects weighing 30-35 grams as much as 24 heads and divided into four groups (K, T1, T2, T3); all groups were inoculated PbA. Group T1 (A. indica leaf extract therapy at a dose of 0.25 mg/grBB), Group T2 (A. indica leaf extract therapy at a dose of 0.5 mg/grBB), Group T3 (A. indica leaf extract therapy at a dose of 1 mg/grBB). Data analysis using the Anova + posthoc test with a significance value of p < 0.05 and CI of 95%. The results showed differences in TGF-β levels, both in the control and treatment groups after treatment, with a p-value of < 0.05. Greater increases in TGF-β levels occurred in the T3 group (average +38.46 pg/ml) compared to group K (average +14.37 pg/ml), group T1 (average +14.37 pg/ml), and group T2 (average +22.13 pg/ml)

Keywords


Azadirachta indica extract; Interleukin-10; Plasmodium Berghei ANKA

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References


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DOI: http://dx.doi.org/10.21043/jobe.v6i1.18807

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